|
KMID : 1145720210090010057
|
|
Korean Herbal Medicine Informatics
2021 Volume.9 No. 1 p.57 ~ p.66
|
|
|
Protective Effects of the Calyx of Diospyros kaki against UVB-induced Oxidative Stress in Human Skin Fibroblast
|
|
Jeong Taek-Young
Heo Hui-Jin
Lim Jin-Yeong
Lee Jun-Soo
Park Jeong-Hwan
|
|
|
Abstract
|
|
|
|
Ultraviolet exposure causes photoaging such as pigmentation, dryness, and wrinkles of the skin. This study investigated the protective effects of the calyx of Diospyros kaki using Human foreskin fibroblast (Hs68) cells against UVB-induced photoaging. The calyx of Diospyros kaki extract was not toxic to Hs68 cells until 20 μg/mL concentration and noticeably increased cell viability compared to the UVB (30 mJ/cm2) treated group. The calyx of Diospyros kaki extract had very strong activity in inhibiting reactive oxygen species production. In addition, the extract significantly reduced the production of MMP-1 and MMP-3. In particular, at 10 and 20 μg/mL concentration, the extract showed a very strong inhibitory effect than the 100 μM of ascorbic acid, which is a positive control. The collagen levels tended to increase markedly by the extract. The calyx of Diospyros kaki can be used as a herbal material that exhibits protective effects against photoaging.
|
|
|
KEYWORD
|
|
|
Diospyros kaki, UVB, fibroblast, collagen, photoaging
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|